Like its crosstown rival UCLA, the USC Trojans won their first game of the season, beating San José State 30-7 at Los Angeles Memorial Coliseum. The Trojans put up the first score, a field goal in 11 plays, in the first quarter and led the entire game.
San José State did not score until the third quarter, a touchdown and extra point. But by then USC had scored a touchdown with extra point and another field goal.
In the fourth quarter, the Trojans scored three more touchdowns, one resulting from an interception.
QB Kedon Slovis ended the game with 24 completions for 256 yards and 2 touchdowns.
USC football schedule
| Opponent | Date and Time | Location | W|L | Score |
| San José State | Sep 4 (Sat) 2 p.m. PT | Los Angeles Memorial Coliseum | W | 30-7 |
| Stanford | Sep 11 (Sat) 7:30 p.m. PT | Los Angeles Memorial Coliseum | ||
| at Washington State | Sep 18 (Sat) 12:30 p.m. PT | Pullman, WA | ||
| Oregon State | Sep 25 (Sat) TBD | Los Angeles Memorial Coliseum | ||
| at Colorado | Oct 2 (Sat) TBD | Boulder, CO | ||
| Utah | Oct 9 (Sat) TBD | Los Angeles Memorial Coliseum | ||
| at Notre Dame | Oct 23 (Sat) 4:30 p.m. PT | Notre Dame, IN | ||
| Arizona | Oct 30 (Sat) TBD | Los Angeles Memorial Coliseum | ||
| Arizona State | Nov 6 (Sat) TBD | Tempe, AZ | ||
| at California | Nov 13 (Sat) TBD | Berkeley, CA | ||
| UCLA | Nov 20 (Sat) TBD | Los Angeles Memorial Coliseum | ||
| vs Brigham Young | Nov 27 (Sat) TBD | Los Angeles Memorial Coliseum | ||
| Pac-12 Championship | Dec. 3 TBD | Las Vegas, NV |